New CRISPR technique skips over portions of genes that can cause disease

Illinois researchers adapted CRISPR gene-editing technology to help a cell skip over mutated portions of genes. From left, professor Pablo Perez-Pinera, graduate student Alan Luu, professor Jun Song and graduate student Michael Gapinske. Photo by L. Brian Stauffer

Editor’s notes: To contact Pablo Perez-Pinera, email: pablo@illinois.edu. To contact Jun Song, call (217) 244-7750; email: songj@illinois.edu.

The paper “CRISPR-SKIP: programmable gene splicing with single base editors” is available online.

Source: Illinois NEWS BUREAU

Summary
New CRISPR technique skips over portions of genes that can cause disease
Article Name
New CRISPR technique skips over portions of genes that can cause disease
Description
CHAMPAIGN, Ill. — In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated.